Are you sitting too long?

Deep Vein Thrombosis – What you should know.

deep vein thrombosis - sitting too longDo you spend long periods of time sitting at your desk, driving in your car, on a plane, or even on your couch watching tv?

If you do, you are at an increased risk of developing deep vein thrombosis (DVT). Deep vein thrombosis is a blood clot that typically collects in a deep vein in your legs. This can cause a fatal pulmonary embolism. (1,2)

According to the American College of Cardiology, if you are sitting for more than 4 hours a day, you are increasing your chance of fatal blood clots (originating in your veins) by 48%. (3)

According to the Centers for Disease Control and Prevention (CDC), as many as 900,000 Americans could be affected by venous thromboembolisms (blood clots that break off and block air to your lungs) every year.11 Compare that to epidemics like all forms of cancer, which kill about 570,000 Americans annually.

sitting 4 hoursResearchers at the American College of Cariology, found that people who sit for 4 hours or more per day had a 125% more likeliness of developing deep vein thrombosis, than those that sat for only 2 hours a day. (12)

Scientists have found that there are certain natural extracts that can block these specific blood clots from forming, help break down small clots before they grow, restore natural anti-clotting factors, and enhance clot-reversal processes. (4-10)

In a placebo controlled study, people taking these plant extracts, experienced zero cases of deep vein thrombosis, while 5.4% of the control group ended up with DVT. (6)

How Deadly Deep Vein Thrombosis (DVT) Occurs

Deep vein thrombosis can occur quickly and without any warning signs. If this clot breaks off and travels through your circulatory system, it can eventually block blood flow to your lungs or a pulmonary embolism. This can be fatal and can happen very quickly as it reduces or entirely stops blood flow to your lungs.

embolismApproximately 30% of people that have the blood clot travel to their lungs, die within one month. About 33% of the people that survive this event, end up having another event occur within the next 10 years. This event of having a blood clot travel to and block the lungs is called Venous thromboembolism and it kills up to  100,000 Americans a year. (11)

While lifestyle changes, like exercise, eating healthy and quiting smoking may help, they are typically not enough on their own. And anticlotting drugs, run the risk of undesired bleeing. (13,14) Unfortunately, these only provide limited protection because clots are formed, faster than they are prevented. (17,18)

Fortunately, there is a dual plant extract formula that has been shown to inhibit venous clot formation and promote elasticity.

What to look for?

Deep vein thrombosis often occurs without any symptoms. But if you notice any of the symtpoms below, call you doctor as soon as possible:27

  • Swelling in one or both legs
  • Tenderness or pain in one or both legs, even if it’s only when standing or walking
  • Warm skin on your leg
  • Red or discolored skin on your leg
  • Veins you can suddenly see
  • Tired legs

How to fight Deep Vein Thrombosis

There are several preventative things you can do every day, that slow down the progression of deep vein thrombosis.

These include getting up every hour or so, stretching and walking around. Using a stand up desk, or while watching tv, tensing and relaxing your leg muscles for 5 minutes for every hour that you are watching.

Scientists have identified two natural ingredients that show powerful preventive effects:

pine barkNattokinase and French maritime pine bark

Nattokinase has been shown to break down fibrin and it precursor fibrinogen ( a long, strand-like molecules that make up the main protein found in clots), both of these are involved in red blood cell-induced clot formation.8,19,20

Nattokinase decreased levels of other factors involved in  blood-clotting and raised levels of factors that prevent clotting, without side effects or bleeding. (4)

French maritime pine bark extract has been shown to reduce platelet aggregation (clumping). It also helps to increase a blood flow boosting enzyme which generates nitric oxide which is extremely importatnt for regulating proper blood vessel function and reduces thrombotic risks.

Nattokinase and pine bark extract were shown to work together to prevent clots as well as to improve the microcirculation of the legs. (9,21)

French maritime pine bark extract also helps to prevent the blood vessels from becoming stiff and reducing blood flow.10,22

Scientists have recognized that these two extracts could result in significant prevention of deep vein thrombosis by:4,7-10,19-22

  1. Inhibiting unwanted clot formation within veins
  2. Improving microcirculation in the veins of the legs
  3. Promoting elasticity of vessel walls
  4. Inducing breakdown of fibrin clots

Human Clinical Trial Combining Nattokinase and French Maritime Pine Bark Extract

“Scientists tested a combination of nattokinase and French maritime pine bark extract in a randomized, placebo-controlled human trial.6

plane passengersThey took 204 passengers on a New York-to-London flight and instructed them in deep vein thrombosis-prevention techniques: isometric exercises, standing and moving for five to ten minutes, and keeping hydrated. The passengers were randomly assigned to receive either a placebo or capsules of the proprietary blend of nattokinase and French maritime pine bark extract. All subjects took their capsules two hours  before departure and again six hours later. Ultrasound scans were done before and after the flight to detect clots.

Passengers taking the supplement had zero deep vein thrombosis cases. However, five of the control passengers developed a deep vein thrombosis, and two others developed superficial clots, for a total of seven events—a 5.4% DVT rate among controls, compared to a 0.0% rate among the test subjects.6 The scientists also measured leg swelling, which was equal between the two groups preflight. Edema increased by 12% in the controls. But edema decreased by 15% in the supplemented passengers.6

These findings confirm that this novel dual-extract formula helps prevent deep vein thrombosis in individuals who spend long periods sitting and reduces the risk of sudden death from a resultant pulmonary embolism. No adverse side effects were reported.”

Deep vein thrombosis is a serious risk for anyone who spends long periods sitting and can lead to a deadly pulmonary embolism.

Fortunately, the combination of Nattokinase and French Maritime Pine Bark Extract prevented deep vein thrombosis in all volunteers who supplemented with it, while also decreasing leg swelling.

venoflowIf you are interested in a product that has both Nattokinase and French Maritime Pine Bark, we recommend VenoFlow. You can learn more about VenoFlow by clicking here

VenoFlow Supports Healthy Circulation In The Extremities

Maintaining healthy blood flow in your arms, legs, and extremities is particularly important for older adults, as well as those forced to endure extended periods of immobility such as long-distance travelers or office workers. Our unique VenoFlow formula combines the potent nattokinase enzyme with Pycnogenol® French maritime pine bark extract to support healthy blood flow, vascular function, and the body’s natural, healthy blood clotting processes.




  1. Available at: Accessed September 19, 2016.
  2. Available at: Accessed September 19, 2016.
  3. Stamatakis E, Hamer M, Dunstan DW. Screen-based entertainment time, all-cause mortality, and cardiovascular events: population-based study with ongoing mortality and hospital events follow-up. J Am Coll Cardiol. 2011;57(3):292-9.
  4. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29(3):190-6.
  5. Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004;10(4):373-7.
  6. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trial. 2003;54(5):531-9.
  7. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601.
  8. Sumi H, Hamada H, Nakanishi K, et al. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43.
  9. Golanski J, Muchova J, Golanski R, et al. Does pycnogenol intensify the efficacy of acetylsalicylic acid in the inhibition of platelet function? In vitro experience. Postepy Hig Med Dosw (Online). 2006;60:316-21.
  10. Grimm T, Schafer A, Hogger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med. 2004;36(6):811-22.
  11. Available at: Accessed September 20, 2016.
  12. Available at: Accessed September 22, 2016.
  13. Hass B, Pooley J, Harrington AE, et al. Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management. Thromb J. 2012;10(1):24.
  14. King DA, Pow RE, Dickison DM, et al. Apixaban versus enoxaparin in the prevention of venous thromboembolism following total knee arthroplasty: a single-centre, single-surgeon, retrospective analysis. Intern Med J. 2016;46(9):1030-7.
  15. Skervin AL, Thapar A, Franchini AJ, et al. Systematic Review and Meta-Analysis of Utility of Graduated Compression Stockings in Prevention of Post-Thrombotic Syndrome. Eur J Vasc Endovasc Surg. 2016;51(6):838-45.
  16. Jin YW, Ye H, Li FY, et al. Compression Stockings for Prevention of Postthrombotic Syndrome: A Systematic Review and Meta-Analysis. Vasc Endovascular Surg. 2016;50(5):328-34.
  17. Favaloro EJ, Franchini M, Lippi G. Aging hemostasis: changes to laboratory markers of hemostasis as we age – a narrative review. Semin Thromb Hemost. 2014;40(6):621-33.
  18. Maroney SA, Mast AE. Platelet tissue factor pathway inhibitor modulates intravascular coagulation. Thromb Res. 2012;129 Suppl 2:S21-2.
  19. Ero MP, Ng CM, Mihailovski T, et al. A pilot study on the serum pharmacokinetics of nattokinase in humans following a single, oral, daily dose. Altern Ther Health Med. 2013;19(3):16-9.
  20. Lampe BJ, English JC. Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto. Food Chem Toxicol. 2016;88:87-99.
  21. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol. 1998;32(4):509-15.
  22. Grimm T, Chovanova Z, Muchova J, et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1.
  23. Fujita M, Ohnishi K, Takaoka S, et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(11):1696-701.
  24. Cesarone MR, Belcaro G, Rohdewald P, et al. Prevention of edema in long flights with Pycnogenol. Clin Appl Thromb Hemost. 2005;11(3):289-94.
  25. Errichi BM, Belcaro G, Hosoi M, et al. Prevention of post thrombotic syndrome with Pycnogenol(R) in a twelve month study. Panminerva Med. 2011;53(3 Suppl 1):21-7.
  26. Beckman MG, Hooper WC, Critchley SE, et al. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4 Suppl):S495-501.
  27. Available at: Accessed September 22, 2016.