“In the field of medicine and health it is one of the revolutions of our time: the discovery that the amino acid L-arginine may be a ‘magic bullet’ for the cardiovascular system. A virtual arterial cleanser, ARGININE helps eliminate blockage and maintains blood flow.

”“Oral ARGININE taken regularly has time and time again proven its ability to lower cholesterol, prevent LDL oxidation by free radicals, restore endothelial function, normalize blood-vessel dilation, reduce platelet stickiness, and generally tune up your cardiovascular system.”

-Woodson Merrell, M.D., Columbia University Medical School
Dr. Robert Fried, PhD., Senior Professor of Biopsychology at Hunter College, Columbia Univ. NY

 

L-ARGININE is a safe, effective, and inexpensive means of self-care that boosts immunity, sexual potency, and general well-being."

-Harold Bloomfield, M.D.

 

• 7 grams of L-arginine per day improved blood flow in men, aged 55 to 77, with elevated serum cholesterol and early coronary artery disease.

-Circulation

 

• L-arginine supplementation reduced pathological increases in the thickness of plaque lined vessel walls in people with elevated cholesterol and artherosclerosis.

-Circulation

 

• Arginine lowered plasma cholesterol levels in patients with advanced hypertension.

-New England Journal of Medicine

 

• Arginine infusion has the same effect in cardiovascular patients as cholesterol-lowering drugs. -The Lancet • 7 grams of L-arginine improved blood-vessel relaxation in young men with elevated serum cholesterol and coronary artery disease (in as few as 3 days).

-Circulation

 

In the best selling book “The Cardiovascular Cure,” the author John Cooke, Ph.D. states that arginine derived nitric oxide (ADNO):

Keeps blood vessels pliable and elastic

Keeps blood flowing smoothly

Keeps platelets calm and prevents them from sticking to the vessel wall

Keeps white blood cells calm and prevents them from sticking to the vessel wall

Reduces growth and multiplication of muscle cells that thicken the vessel wall

Slows plaque growth and suppresses atherosclerosis

May melt away plaque that already exists

To date arginine has been shown in animal as well as human trials that it may be effective in the following:

Decreasing and reversing atherosclerosis by decreasing intimal thickening and monocyte accumulation 9,10,11,12,13,14

• Restore normal endothelial function in hypercholesterolemia 14,15,16,17,18,19,20,21

Reversing consequences of coronary artery disease 22,23,24,25,26,27,28,29,30

Decreasing cholesterol and triglycerides
32

Improves walking distance in peripheral vascular disease 31,33,34,35,36

• Improves pain in interstitial cystitis 37,38

• Prolonged administration of arginine reverses adverse effects of high blood pressure 39,40,41,42

Decreases high blood pressure 43

• Decreases post operative infection and length of stay 44

Increases human growth hormone 45,46,47,48,49,50,116

• Improves outcome after bypass surgery 51

Improves sexual function 52

Improves exercise tolerance 53,54

• Improves renal function 55,56,57,58,59,60

• Improves glucose uptake in muscle cells 61

Improves asthma 61,62,63,64,65,66

• Improves cell mediated immunity 67,68,69,70,71

• Improves pituitary responsiveness and modulates hormonal control 72,73,74

• Improves muscle performance 75

Improves diabetes and reverses damage 76,77,78,79

May prevent diabetes 78

Reduces blood clots and strokes 80,81,82

• Helps prevent restenosis after angioplasty and bypass 83,84,85

• Helps prevent post surgical damage after intestinal manipulation 86

May improve irritable bowel syndrome 87

Improves osteoporosis 88

• May improve prostate function 89

• May give protection against size of heart attack 90

• Helps protect in cardiac transplants 91,92

• Improve scleroderma 93

Improve sickle cell disease 94

• Prevent pre-eclampsia 95

• Improves exercise capacity in pulmonary hypertension 96,117,118

• Improves wound healing 97,98,99

Reduces ulcers 101,102

Improves peripheral vascular disease 103,104

• Improves outcome in sepsis 105

Improves conditions of heart failure 106

• Improves outcome of cancer treatment 107,108

Improve alzheimer’s 109,110,111,112

Improves memory and cognitive functions 113,114,115

• L-arginine has been shown to safe in the above studies as well as others 100,116


The information herein is not intended to replace the medical advice of your physician. You are advised to consult with your physician with regards to matters relating to your health, and in particular regarding matters that may require diagnosis or medical attention. DO NOT stop taking medications without first consulting with your physician. These statements have not been evaluated by the Food and Drug Administration.

Every effort has been made to ensure that the information provided herein is accurate, up-to-date, and complete, but no guarantee is made to that effect. This information has been compiled for use by healthcare practitioners and consumers in the United States. Heart 2 Heart of America does not endorse drugs, diagnose patients or recommend therapy. This informational resource is designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Heart 2 Heart of America does not assume any responsibility for any aspect of healthcare administered with the aid of information Heart 2 Heart of America compiles. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions, check with your doctor, nurse or pharmacist

© Copyright 2003. All rights reserved

 

References
1. Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner Books, 1999.
2. Coffee, C J: Metabolism. Madison, Ct: Fence Creek Publishing, 1998.pp388-389
3. Catt KJ: Molecular Mechanisms of Hormone Action. In Endocrinology and Metabolism, 3rd ed. Edited by Felig P,
Baxter JD, Frohman LA. New York, NY: McGraw-Hill, 1995, pp 138-139
4. Gerhard M, et al. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels
of humans. Hypertension 1996 Apr;27(4):849-53
5. Toprakci M, et al. Age-associated changes in nitric oxide metabolites, nitrite and nitrate. Int J Clin Lab Res
2000;30(2):83-5
6. Sakuma I, et al. Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc Natl Acad
Sci USA 1988 Nov;85(22):8664-7
7.Vallance P, Moncada S. Nitric Oxide—from mediator to medicines. J R Coll Physicians Lond 1994 May-Jun;28
(3): 209-219
8. Kam PC, Govender G. Nitric oxide: basic science and clinical applications. Anaesthesia 1994 Jun;49(6): 515-21
9. Sinha G. Viagra: ups and downs. Popular Science 2000 July: page 35
10. Boger RH, Bode-Boger SM, Kienke S, et al. Dietary L-arginine decreases myointimal cell proliferation and
vascular monocyte accumulation in cholesterol-fed rabbits.Atherosclerosis 1998 Jan;136(1) 67-77
11. Cheng JW, Balwin SN. L-Arginine in the management of cardiovascular diseases. Ann Pharmacother 2001
Jun;35(6):755-64
12. Tentolouris C, Tousoulis D, et al. L-Arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep 15;75(2-
3):123-8
13. Wang B, Ho HV, et al. Regression of atherosclerosis. Circulation 1999;99(9):1236-41
14. Boger RH, Bode-Boger SM, et al. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol
fed rabbits: comparison with lovastatin. Circulation 1997; 96(4):1282-90
15. Schuschke DA, Miller FN, Lominadze DG, Feldhoff RC. L-arginine restores cholesterol-attenuated micro
vascular responses in the rat cremaster. Int J Micricirc Clin Exp 1994 Jul-Aug;14(4): 204-11
16. Orlandi A, Marcellini M Spagnoli LG. Aging influences development and progression of earl aortic
atherosclerosis lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasac Biol 2000 Apr;20
17. Chong PH, Bachenheimer BS. Current, New and future treatments in dyslipidemia and atherosclerosis. Drugs
2000 Jul;60(1):55-93
18. Phivthong-ngam L, Bode-Boger SM, Boger RH, et al. Dietary L-arginine normalizes endothelial induced
vascular contractions in cholesterol-fed rabbits. J Cardiovasc Pharmacol 1998 Aug;32(2): 300-7
19. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed
by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16
20. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelial-dependent dilation in
hypercholesterolemic young adults. J Clin Invest 1996 April; 97(8): 1989-94
21. Cooke JP, Dzau J, Creager A. Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Basic
Res Cardiol 1991; 86 Suppl 2: 173-81
22. Fraser GE. Diet and coronary heart disease: beyond dietary fats and low-density-lipoprotein cholesterol. Am J
Clin Nutr 1994 May;59(5 Suppl) 1117s-1142sand atherosclerosis. Drugs 2000 Jul;60(1):55-93
23. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve
myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11
24. Lerman A, Burnett JC Jr, Higano ST, et al. Long-term L-arginine supplementation improves small vessel
coronary endothelial function in humans. Circulation 1998 Jun 2;97(21):1648-9
25. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise
capacity in patients with stable angina pectoris. Am J Cardiol 1997 Aug 1; 80(3):331-3
26. Desrois M, Sciaky M, Lan C, et al. L-arginine during long-term ischemia: effects on cardiac function, energetic
metabolism and endothelial damage. J Heart Lung Transplant 2000 April; 19(4): 367-76
27. Quyyumi AA, Dakak N, Dodati JG, et al. Effect of L-arginine on human coronary endothelium-dependent and
physiologic vasodilation, J AM Coll Cardiol 1997 Nov 1; 30(5):1220-7
28. Egashira K, et al. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in
patients with angina pectoris and normal coronary arteriograms. Circulation 1996;94(2):130-4
29. Tentoluris C, et al. L-arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep15;75(2-3):123-8
30. Tretjakovs P, Kalnins U, Dabina I, et al. Plasma HDL-cholesterol has an effect on nitric oxide production and
arachidonic production in the platelet membranes of coronary artery disease patients without LDLhypercholesterolemia.
Med Sci Monitor 2000 May- Jun;6(3):507-11
31. Bode-Boger SM, Boger RH, Galland A, Tsikas D Frolich JC. L-arginine induced vasodilatation in healthy
humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998 Nov; 46(5): 489-97
32. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega)
nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996
Oct;126(10):2563-7
33. Boger RH, Bode-Boger SM, Theil W, et al. Restoring vascular nitric oxide formation by L-arginine improves
symptoms of intermittent claudication in patients with Peripheral arterial occlusive disease. J Am Col Cardiol
1998 Nov;32(5):1336-44
34. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19
35. Hiatt WR. New treatment options in intermittent claudication: the US experience. Int J Clin Pract Suppl 2001
Apr;(119):20-27
36. Creager MA. Medical management of peripheral artery disease. Cardiol Rev 2001 Jul-Aug;9(4):238-45
37. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral Larginine
for treatment of interstitial cystitis. J Urol 1999 Feb; 161(2):558-65
38. Cartledge JJ, Davies AM, Eardley I. A randomized double-blind placebo-controlled crossover trial of the
efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000 Mar; 85(4):421-6
39. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial
hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1
Pt 2):451-5
40. Higashi Y, et al. Effects of L-arginine infusion on renal hemodynamics in patients with mild hypertension.
Hypertension1995;25(4):898-902
41. Hishikawa K, et al. Role of L-arginine-nitric oxide pathway in hypertension. J Hypertens 1993 Jun; 11(6):639-45
42. Dominiczak AF, Bohr DF. Nitric oxide and its’ putative role in hypertension. Hypertension 1995;25(6):1202-11
43. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7
44. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery:
results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33
45. Ghigo E, Aimaretti G, Cornelli G, et al. Diagnosis of GH deficiency in adults. Growth Hormone IGF Res 1998
Feb;8 Suppl A:55-8
46. Wideman L Weltman JY, Patrie JY, et al. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in
men and women: modulation by exercise. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1467-77
47. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human
insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in
humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8
48. Mauras N, Walton P, Nicar M, et al. Growth hormone stimulation testing in both short and normal statured
children. Pediatr Res 2000 Nov;48(5):579-80
49. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the
human life span. J Pediatr Endocrinol Metab 2000;13 Suppl 6:1493-502
50. Korbonits M, Kaltsas G, Perry LA, et al. The growth hormone secretagogue hexarelin stimulates the
hypothalamo-pituitary-adrenal axis via arginine vasopressin. J Clin Endocrinol Metab 1999 Jul;84(7):2489-95
51. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients
undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8
52. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with
organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73
53. Kobayashi N, Nakamura M, Hiramori K. Effects of infusion of L-arginine on exercise-induced myocardial
ischemic changes and capacity to exercise of patients with stable angina pectoris. Coron Artery Dis 1999
Jul;10(5):321-6
54. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT
dispersion and exercise tolerance in stable angina pectoris.Int J Cardiol 2000 Sep 15; 75(2-3): 205-10
55. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine
supplementation in chronic renal failure. Kidney Int 1999 Aug;56(2):674-84
56. Watanabe G, Tomiyama H, Doba N. Effects of oral L-arginine on renal function in patients with heart failure. J
Hypertens 2000 Feb;18(2):229-34
57. Kelly BS, Alexander JW Dreyer D, et al. Oral arginine improves blood pressure in renal transplant and
hemodialysis patients. J Parenter Enteral Nutr 2001 Jul-Aug; 25(4): 194-202
58. Efron DT, Barbul A. Arginine and nutrition in renal disease. J Ren Nutr 1999 Jul;9(3):142-4
59. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal
function. Am J Physiol 1997 Jun; 272(6 Pt 2):1768-74
60.Reyes AA, Purkerson ML, Karl L, Klahr S. Dietary supplementation with L-arginine ameliorates the
progression of renal disease in rats with subtotal nephrectomy. Am J Kidney Dis 1992 Aug; 20(2):454-5
61. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not
blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21
62. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness
to histamine in asthma. Thorax 1999 Nov;54(11):1033-5
63. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy
and asthmatic subjects. J Appl Physiol 2001 Feb;90(2):586-92
64. Boer J, et al. Role of L-arginine deficiency of nitric oxide and airway hyperreactivity after allergen-induced
early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 Nov;128(5):1114-20
65. Blease K, Kunkel SL, Hogaboam CM. Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness,
eosinophilia and C-C chemokine generation in a murinemodel of fungal asthma. Inflamm Res 2000 Jun;
49(6):297-304
66. Du J, Cui D, Tian D. [ The role of nitric oxide in the pathogenesis of asthma.] [ Full text in Chinese] Zhonghua
Jie He He Hu Xi Za Zhi 1997 Jun;20(3):153-6
67. Gionotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an
arginine-, omega-3 fatty acid-, and RNA enriched enteral diet: effect on host response and nutritional status. J
Parenter Enteral Nutr1999 Nov- Dec;23(6):314-20
68. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroentol 2000;35 Suppl 12:20-3
69.Lewis B, Langkamp-Henken B. Arginine enhances in vivo immune responses in young, adult and aged mice.
J Nutri 2000;130(7):1827-30
70. Mannick JB, et al. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus
reactivation. Cell 1994 Dec 30;79(7):1137-46
71.Ochoa JB, et al. Effects of L-arginine on the proliferation of T-lymphocyte subpopulations. J Parenter
Enteral Nutr 2001 Jan-Feb;25(1):23-9
72. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in
athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54
73. Lawecki J et al. Serum insulin, pancreatic glucagons and growth hormone levels in response to intravenous
infusion of L-arginine in patients with recently detected juvenile diabetes. Pol Med Sci Hist Bull 1976 Apr-
Jun;15(2):177-82
74. Valcenti S, et al Biphasic effect of nitric oxide on testosterone and cyclic GMP productionby purified rat Leydig
cells cultured in vivo. Int J Androl 1999 Oct; 22(5):336-41
75. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance
enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-8
76. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine administration improves peripheral and
hepatic insulin sensitivity in type 2 diabetes. Diabetes Care 2001 MAY;24(5):875-80
77. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997;
95(7):1783-90
78. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free
Radic Biol Med 1998 Nov 1;25(7):757-65
79. Mendez JD, Balderas F. Regulation of hyperglycemia and dyslipidemia by exogenous L-arginine in Diabetic
rats. Biochemie 2001 May;83(5):453-8
80. Kaposzta Z, et al. L-arginine and S-nitroglutathione reduce embolization in Humans. Circulation
2001;103(19):2371-75
81. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2
formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150
82. Wolf A, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic
humans. J Am Coll Cardiol 1997 Mar 1; 29(3):479
83. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon
angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82
84. Janero DR, Ewing JF. Nitric Oxide and Postangioplasty re-stenosis: Pathologicalcorrelates and therapeutic
potential. Free Radic Biol Med 2000 Dec 15;29(12):1199-221/login?_sid=pA9K2IlHelvFq5Sm39sxDVozX3 gt; 85. Severin P, et al. Local intramural delivery of l-arginine enhances nitric oxide generation and inhibits lesion
formation after balloon angioplasty. Circulation 1997;95(7):1863-9
86. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by
laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32
87.Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon
smooth muscle and the role of K+channels in these responses.. Methods Find Exp Clin Pharmacol 2001 Jan-
Feb;23(1):13-7
88. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats
Biomed Pharmacother 2001 May;55(4):213-21
89. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the
rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6
90. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in
isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9
91. Koglin J. Pathogenetic mechanisms of cardiac allograft vasculopathy-impact of nitric oxide. Z Kardiol 2000;89
Suppl 9:IX/24-7
92. Kown MH, Van Der Steenhoven T, Uemura S, et al. L-Arginine polymer mediated inhibition of graft coronary
artery disease after cardiac transplantation. Transplantation 2001 June 15;71(11):1542-8
93. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma.
Lancet 1999 Aug 28:354;739
94. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with
vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20
95. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in patients with pre-eclampsia and essential
hypertension. Med Sci Monitor 2000 Sep-Oct;6(5):901-7
96. Nagaya N, Uematsu M, et al. Short term oral administration of l-arginine improves hemodynamics and exercise
capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med 2001
April;163(4):887-91
97. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responsesin humans. Surgery 1990
Aug;108(2):331-6; discussion 336-7
98. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery 1993
Aug;114(2):155-9; discussion 160
99. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri 1998 May;128(5):797-803
100. Blum A, Cannon RO, Costello R, et al. Endocrine and lipid effects of oral L-arginine treatment in healthy
postmenopausal women. J Lab Clin Med 2000 Mar;135(3):231-7
101.Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and
its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res 2001 Jun;43(6):535-41
102. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration
by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7
103. Calver A, Collier J, Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci 1991
Nov;81(5):695-700
104. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical
limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90
105. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.
106. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise
training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13
107. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in
patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41
108. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer(> 4cm.) receiving
multi-modality treatment: report of a feasibility study. Br J Cancer 1994 May;69(5):918-21
109. McCarty MF. Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer’s
disease by suppressing synthesis of acute-phase cytokines. Med Hypotheses 1999 Nov;53(3):369-74
110. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement
Geriatr Cogn Disord 2000 Nov- Dec;11(6):322-6
111. de la Torre JC, Stefano GB. Evidence that Alzheimer’s disease is a microvascular disorder: the role of
constitutive nitric oxide. Brain Res Brain Res Rev 2000 Dec;34(3):119-36
112. Kuiper MA, et al. Decrease cerebrospinal fluid nitrate levels in Parkinson’s disease, Alzheimer’s disease and
multiple system atrophy patients. J Neurol Sci 1994 Jan; 121(1):46-9
113. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory
impairment. Med Hypotheses 1994 Jun;42(6):363-6
114. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric
oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82
115. Pendergast MA, et al. Nitric oxide synthase inhibition impairs delayed recall in mature monkeys. Pharmacol
Biochem Behav 1997 Jan;56(1):81-7
116. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults.Medicina (B Aires) 1999;
59(3):249-53
117. Fagan JM, et al. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension.
Biochem Biophys Res Commun 1999 Jan 8; 254(1):100-3
118. Nitric oxide and pulmonary hypertension. Coron Artery Dis 1999 Jul; 10(5):287-94