Metolazone (Zaroxolyn, Mykrox)- What You Should Know

Brand Name: Zaroxolyn, Mykrox

What is Metolazone (Zaroxolyn, Mykrox)?

The information about Metolazone (Zaroxolyn) contained herein is a compilation of materials available from and simplified for the average consumer.

Metolazone (Zaroxolyn)Metolazone, also known by brand names Zaroxolyn and Mykrox is a diuretic that helps rid your body of salt (sodium) and water. Metolazone is a quinazoline diuretic that is used when, a person has kidney problems or when other diuretics have not worked. Metolazone works by causing the kidneys to eliminate certain chemicals which allow large amounts of water to be eliminated.

There are drug free alternatives to lowering your blood pressure that may be effective for you. Read about them here.

Caution, losing too much sodium or other minerals (e.g., zinc, potassium and magnesium) in the urine can lead to serious new problems.

How to use Metolazone (Zaroxolyn):

  • taking pillUse Metolazone (Zaroxolyn) as directed by your doctor. Check the medicine label for exact dosing instructions.
  • Take it by mouth with food to avoid upset stomach.
  • Take Metolazone (Zaroxolyn) before 6 PM as frequent urination may occur.
  • If you miss a dose of Metolazone (Zaroxolyn), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metolazone (Zaroxolyn).

What to know before using Metolazone (Zaroxolyn):

If any of the following apply to you, discuss with your doctor before taking Metolazone (Zaroxolyn):

  • lupusMetolazone Zaroxolyn gout
  • kidney or liver disease
  • low blood sodium
  • low potassium levels
  • gout
  • pregnant, planning to become pregnant, or are breast-feeding
  • taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • have allergies to medicines, foods, or other substances
  • Are using a salt substitute or a product that has potassium in it.
  • Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Metolazone (Zaroxolyn). These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Metolazone (Zaroxolyn) should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

Some medicines may have negative interactions with Metolazone (Zaroxolyn).  Ask your doctor before you start, stop, or change the dose of any medicine and check if any of your medications will interact with Metolazone (Zaroxolyn).

The side effects of the below medications may be increased by Metolazone (Zaroxolyn).

  • Nonsteroidal antiinflammatory drugs (NSAIDs) (ex, ibuprofen, naproxen).medication
  • Angiotensin-converting enzyme (ACE Inhibitors)(eg, enalapril)
  • allopurinol
  • amantadine
  • antineoplastic agents (ex. cyclophosphamide)
  • diazoxide
  • digitalis glycosides (ex. digoxin)
  • ketanserin
  • lithium
  • loop diuretics (ex. furosemide)
  • nondepolarizing muscle relaxants (ex. vecuronium)

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metolazone (Zaroxolyn) may interact with other medicines that you take.

Side effects of Metolazone (Zaroxolyn):

Get medical attention right away if you have any of these symptoms:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)vitamin c heart attack
  • chest pain/discomfort
  • depression
  • drowsiness
  • dry mouth
  • fainting
  • gout attacks
  • light headed when rising from a seated position
  • muscle pain or cramps
  • rapid or irregular heartbeat
  • restlessness
  • unusual thirst
  • unusual tiredness or weakness
  • vomiting
  • yellowing of the skin or eyes.

If any of the following symptoms of overdose occur while taking metolazone, get emergency help immediately:

Symptoms of overdosefainting

  • Fainting
  • irregular, fast or slow, or shallow breathing
  • pale or blue lips, fingernails, or skin
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • weakness and heaviness of legs

Stop using Metolazone (Zaroxolyn) and call your doctor at once if you have any of these side effects:

  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of skin
  • bloating
  • blood in urine or stools
  • blurred vision
  • bone pain
  • chills
  • clay-colored stools
  • cold sweats
  • coma
  • confusion
  • constipation
  • convulsions
  • cough
  • dark urine
  • decreased urine
  • diarrhea
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • incoherent speech
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • irritability
  • itching
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • metallic taste
  • mood changes
  • muscle pain or cramps
  • nausea and vomiting
  • numbness or tingling in hands, feet, or lips
  • pain in lower legs
  • painful or difficult urination
  • pinpoint red spots on skin
  • rash
  • red irritated eyes
  • red skin lesions, often with a purple center
  • redness or swelling of lower leg
  • sore throat
  • sores, ulcers, or white spots in mouth or on lips
  • sugar in the urine
  • sweating
  • swelling of face, ankles, or hands
  • swollen or painful glands
  • trembling
  • unexplained weight loss
  • unpleasant breath odor
  • unusual bleeding or bruising
  • upper right abdominal pain
  • vomiting of blood
  • weak pulse
  • wheezing

The information about Metolazone (Zaroxolyn) comes from

Metolazone (Zaroxolyn) Natural Alternatives:

tikvawithdrinkIf you are taking Metolazone (Zaroxolyn) or other diuretic medications, the various ingredients  in Tikva have been proven through either clinical trials or other research to lower your blood pressure naturally by dilating (widening) the arteries. Tikva does not act as a diuretic.

Several of the ingredients in Tikva can also increase circulation, dissolve plaque that is already in the arteries and reduce new plaque from forming. In addition, there are ingredients in Tikva to help reduce stress that often increases blood pressure without all of the side effects.
Read more about the natural ingredients in Tikva on our research and ingredients page, by clicking here.

watermellonVarious herbs, foods and beverages offer a natural diuretic effect; however, they should be used with caution, in the event of unknown medical conditions with fluid retention as a symptom, or due to side effects with other medications. Consult with your physician prior to using natural diuretics.

Cutting back on sodium and exercising more can also help reduce fluid buildup.

Eating more fruits and vegetables that act as diuretics, like watermelon, grapes, berries, celery, asparagus, onions, garlic, and bell peppers, may be another beneficial solution.

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