Stop Dangerous Cortisol

cortisolCortisol is known as the  “stress hormone”, however, it is more than a hormone released during stress. It is important to understand  how it affects your body.

What Is Cortisol?

Cortisol is a steroid hormone made in your adrenal glands and controlled by your hypothalamus, pituitary gland and your adrenal gland.

What It Does

Cortisol can help control blood sugar levels, regulate metabolism,  reduce inflammation and assist with forming memories. It can help to support a developing fetus during pregnancy. It plays an important role in obesity, aging, hypertension, type II diabetes, and cardiovascular risk, as well as increased risk of infection, osteoporosis, depression, and even neurodegenerative diseases like Alzheimer’s. These functions make cortisol crucial to protect overall health and well-being. 2,3,7-12

One way stress inflicts its deadly damage is by raising cortisol levels.Resulting in accelerated aging, wreaking havoc on your body.

Increased cortisol levels age your internal organs and make you appear older than you are.2

natural stress relief tiredPeople with elevated cortisol have higher mortality rates and are at an incresed risk of cardiovascular disease, diabetes, metabolic syndrome, and neurodegenerative disorders.3-6

Many doctors will prescribe addictive stress and anxiety medications, which helps for the short term, but many patients build up a tolerance to them, which makes them less effective over time.

Fortunately, researchers have found natural ways to reduce cortisol levels.

Life-Threatening Dangers of High Cortisol

When you experience chronic stress, your cortisol levels increase to unhealthy levels.

Recent studies have shown that if your levels are elevated for a long period, you have a much higher risk of dying. One study showed that men with high cortisol levels were 63% more likely to die and women were 82% more likely to die than people that had lower cortisol levels.7

Risk of cardiovascular deaths is more pronounced in people with high cortisol levels. One study found a 5x increase in cardiovascular deaths even in people that initially had no cardiovascular issues.3

agingIn another study, researchers found that people with high cortisol levels were perceived to look older in facial photographs.  Perceived age is well known to be associated with illness and the risk of death.2

“There is even submicroscopic evidence that cortisol accelerates aging. Chronically high cortisol levels are associated with shortening of telomeres, the “fuse-like” stretches of DNA that cap the ends of our chromosomes.13,14 As telomeres shorten, the cells that bear them get closer and closer to the ends of their useful lives, eventually aging the tissues and organs in which they dwell.”

-LEF.org

Reducing stress helps, but often times, stress is unavoidable, so it is important to focus on reducing the cortisol that is induced by stress, even if you can not fully eliminate the stress itself.

That is what has scientists so excited about these natural compounds that can lower cortisol levels.

Lychee Polyphenols Reduce Cortisol Levels

lycheeThe lychee fruit has been grown in China since at least the 11th century.15 It is rich in polyphenols that promote a variety of biological activities, most notably the ability to fight oxidative stress, inflammation and lower cortisol levels.16

Most lychee polyphenol products available in stores contain long-chain polyphenols which are not easily absorbed in the intestinal tract.

Using a proprietary process, scientists are now able to reduce the polyphenol size through steps that include the addition of green tea catechins.17 This allows the new molecule to be stable and highly bioavailable. When researchers tested the bioavailability of the lychee-green tea blend in humans, they found that the polyphenol content in blood was 3 times higher in comparison to ordinary lychee extract alone.18

Human studies show that the lychee-green tea blend can reduce circulating cortisol levels, and can also oppose other physiological effects of stress.

In one study, scientists enrolled 19 sedentary, but otherwise healthy, male volunteers.16 Subj.ects were randomly assigned to receive either a placebo or 100 mg of the new lychee-green tea blend in water each day for 4 weeks. Subjects underwent blood tests for cortisol, markers of inflammation, and other basic evaluations, before and after the supplementation period.

At the end of treatment, lychee-green tea blend recipients, but not placebo users, had significant decreases in cortisol levels.

Tree Bark Extracts Help Lower Cortisol

pine barkExtracts of Magnolia officinalis bark have been previously studied for their anti-anxiety effects, but without the troubling side effects characteristic of anti-anxiety medications.33 An extract from the bark of the Asian tree Phellodendron amurense, has been tested in an animal model of stress, and demonstrated significant reductions in stress manifestations without sedation.33

Human studies of the combination of extracts have demonstrated both their stress-relieving properties and their ability to mitigate stress-induced cortisol elevations. In one such study, researchers enrolled 56 moderately stressed but otherwise healthy men and women.34 Subjects supplemented with 250 mg of the mixed bark extracts twice daily, or received a placebo, for a 4-week period.

After the supplementation period, cortisol levels were 18% lower in the supplemented group than in the placebo recipients. This reduction in cortisol levels was accompanied by improvements in mood and reductions in stress, depression, anger, and fatigue, all of which could be interpreted as related to the lower cortisol levels.

Two other studies have evaluated the combined bark extract supplement at a dose of 250 mg, three times daily. In one, conducted in otherwise healthy overweight, premenopausal women, the supplement significantly decreased anxiety as measured by a variety of scales and scores.33 In the other, the placebo group had significant weight gain over 6 weeks, which was prevented in the supplemented subjects.35

In both studies, the supplemented subjects also had reductions in cortisol levels compared with placebo, but the differences did not reach statistical significance, probably because of the relatively small sample size of these studies.

If you are looking for a way to get your cortisol under control naturally:

Natural Cortisol Balance

30 vegetarian capsules

cortisol

1 Bottle – $33.50 + $9.95 S/H

4 Bottles – $120 (Save $23.95)

Millions of Americans simply accept stress as part of our fast-paced, modern lifestyles. But stress factors can affect cortisol levels, a steroid hormone naturally produced by your body. The special Relora® and Oligonol® ingredient blends in Natural Cortisol Balance support healthy cortisol levels, thereby promoting a healthy response to mood and general fatigue.

Benefits at a Glance:

  • Significantly affects cortisol levels
  • Promotes a healthy biological response to stress
  • Supports healthy mood and sense of vigor

Relora® promotes healthy cortisol response to stress

Relora® is a proprietary blend of Magnolia officinalis and Phellodendron amurense bark extracts. Studies show that Relora® affects salivary cortisol levels, encouraging a healthy stress response. Relora® also binds to neurochemical receptors which regulate mood and stress levels, and supplementing with Relora® improved mood scores on standardized tests.1

Oligonol® helps inhibit pro-inflammatory compoundsOligonol® is a unique, time-release blend of lychee fruit and green tea extracts. In a random, placebo-controlled study, Oligonol® helped inhibit pro-inflammatory IL1β and IL6 cytokines which when left unchecked, encourage increased cortisol activity and biological stress response.2

Natural Cortisol Balance is the only nutritional supplement formula to combine these two proprietary extract blends into a single, natural stress-support supplement. So don’t stress — add Natural Cortisol Balance to your nutritional regimen today.

Supplement Facts
Serving Size 1 vegetarian capsule
Servings Per Container 30
Amount Per Serving
Relora® [proprietary blend of magnolia (bark), phellodendron (bark) extracts] 500 mg
Oligonol® [proprietary blend of lychee (fruit), green tea (leaf) extracts] 100 mg
Other ingredients: corn starch, vegetable cellulose (capsule), silica.

Relora® is a registered trademark of Interhealth N.I. Oligonol® is a registered trademark of Amino Up Chemical Co., Ltd.

Dosage and Use
  • Take one (1) capsule daily, with or without food, or as recommended by a healthcare practitioner.
Caution
Do not take if pregnant or lactating.
Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

References

  1. Christensen H, Boysen G, Johannesen HH. Serum-cortisol reflects severity and mortality in acute stroke. J Neurol Sci. 2004;217(2):175-80.
  2. Noordam R, Gunn DA, Tomlin CC, et al. Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study 2012;37(10):1669-75.
  3. Vogelzangs N, Beekman AT, Milaneschi Y, et al. Urinary cortisol and six-year risk of all-cause and cardiovascular mortality. J Clin Endocrinol Metab. 2010;95(11):4959-64.
  4. Hackett RA, Kivimaki M, Kumari M, et al. Diurnal Cortisol Patterns, Future Diabetes, and Impaired Glucose Metabolism in the Whitehall II Cohort Study. J Clin Endocrinol Metab. 2016;101(2):619-25.
  5. Constantinopoulos P, Michalaki M, Kottorou A, et al. Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients. Eur J Endocrinol. 2015;172(1):69-78.
  6. Bernardi F, Lanzone A, Cento RM, et al. Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer’s disease and vascular dementia. Eur J Endocrinol. 2000;142(5):466-71.
  7. Schoorlemmer RM, Peeters GM, van Schoor NM, et al. Relationships between cortisol level, mortality and chronic diseases in older persons. Clin Endocrinol (Oxf). 2009;71(6):779-86.
  8. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012;109(16):5995-9.
  9. Duggal NA, Upton J, Phillips AC, et al. NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. Age (Dordr). 2015;37(1):9748.
  10. Notarianni E. Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer’s disease initiation and development. Curr Alzheimer Res. 2013;10(7):714-31.
  11. Popp J, Wolfsgruber S, Heuser I, et al. Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer’s type. Neurobiol Aging. 2015;36(2):601-7.
  12. Toledo JB, Toledo E, Weiner MW, et al. Cardiovascular risk factors, cortisol, and amyloid-beta deposition in Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2012;8(6):483-9.
  13. Aulinas A, Ramirez MJ, Barahona MJ, et al. Telomeres and endocrine dysfunction of the adrenal and GH/IGF-1 axes. Clin Endocrinol (Oxf). 2013;79(6):751-9.
  14. Tomiyama AJ, O’Donovan A, Lin J, et al. Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012;106(1):40-5.
  15. Available at: https://hort.purdue.edu/newcrop/morton/lychee.html. Accessed November 21, 2016.
  16. Lee JB, Shin YO, Min YK, et al. The effect of Oligonol intake on cortisol and related cytokines in healthy young men. Nutr Res Pract. 2010;4(3):203-7.
  17. Available at: http://oligonol-net.com/e/about.html. Accessed November 22, 2016.
  18. Miura T, Kitadate K, Fujii H. The Function of the Next Generation Polyphenol, “Oligonol”. Biotechnology in Functional Foods and Nutraceuticals: CRC Press;2010:91-102.
  19. Nagasawa J, Sugiyama K, Uchimaru J. Oxidative stress in hypobaric and normobaric hypoxia and antioxidant effect of Oligonol. Japan J Mountain Med. 2010;30:118-24.
  20. Shin Y-O, Lee J-B, Min Y-K, et al. Effect of oligonol intake on cortisol and cytokines, and body temperature after leg immersion into hot water. Food Science and Biotechnology. 2011;20(3):659-63.
  21. Available at: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2567.2002.01447.x/epdf. Accessed December 1, 2016.
  22. Scheller J, Chalaris A, Schmidt-Arras D, et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011;1813(5):878-88.
  23. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106(5):506-12.
  24. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70.
  25. Ferrucci L, Harris TB, Guralnik JM, et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 1999;47(6):639-46.
  26. Hubbard RE, O’Mahony MS, Savva GM, et al. Inflammation and frailty measures in older people. J Cell Mol Med. 2009;13(9b):3103-9.
  27. Maggio M, Guralnik JM, Longo DL, et al. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006;61(6):575-84.
  28. Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev. 2005;126(2):351-61.
  29. Lee J, Shin Y, Murota H. Oligonol supplementation modulates plasma volume and osmolality and sweating after heat load in humans. J Med Food. 2015;18(5):578-83.
  30. Lee JB, Shin YO. Oligonol supplementation affects leukocyte and immune cell counts after heat loading in humans. 2014;6(6):2466-77.
  31. Lee JB, Shin YO. Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans. Food Funct. 2014;5(10):2516-20.
  32. Shin YO, Lee JB, Song YJ, et al. Oligonol supplementation attenuates body temperature and the circulating levels of prostaglandin E2 and cyclooxygenase-2 after heat stress in humans. J Med Food. 2013;16(4):318-23.
  33. Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008;7:11.
  34. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013;10(1):37.
  35. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006;12(1):50-4.

 

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