Super K – Protect Against Arterial Calcification

Super K – Protection Against Arterial Calcification, Bone Loss, Cancer, and Aging!

super kAn abundance of human clinical data reveals that vitamin K found in Super K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone.6-10

Vitamin K is also required by calcium-regulating proteins in the arteries. Matrix Gla-protein (MGP) is a vitamin K-dependent protein, and it must be carboxylated to function properly. Poor vitamin K status leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification.11,12

Since MGP is a potent local inhibitor of arterial calcification, MGP is important in relation to the health of the entire cardiovascular system. Without adequate vitamin K, calcium in the blood can bind to the arterial wall resulting in calcification.13,14 As people age, even a subclinical vitamin K deficiency can pose risks to the vascular system. Poor vitamin K status also results in increased circulating levels of undercarboxylated osteocalcin that is shown to be associated with increased bone loss in postmenopausal women.15,16

Humans get most of their vitamin K from green vegetables in the form of vitamin K1. The problem is that K1 is tightly bound to plant fiber and only a small fraction absorbs into the bloodstream.17-19

super k eggVitamin K2 (menaquinones) is found in meat, eggs, and dairy products and is also made by bacteria in the human gut, which provides a certain amount of the human vitamin K requirement.20

Human studies show that vitamin K2 is up to ten times more bioavailable than K1. Vitamin K2 remains biologically active in the body far longer than K1. For instance, K1 is rapidly cleared by the liver within eight hours, whereas measurable levels of K2 (MK-7) have been detected 72 hours after ingestion.10

The Rotterdam Heart Study, a large-scale, well-controlled clinical trial that tracked 4,800 participants for seven years, revealed that participants who ingested the greatest quantities of vitamin K2 in their diet experienced a better cardiovascular condition than people who ingested the least.21

High intakes of vitamin K2 also corresponded to less calcium deposition in the aorta, whereas participants who ingested less K2 were more likely to show moderate or severe calcification. Animal studies suggest vitamin K intake not only blocks the progress of further calcium accumulation, but also induces 37% regression of preformed arterial calcification.22,23

Ideal Forms of Vitamin K2 Found in Super K

In recent years, two forms of vitamin K2 have been extensively researched and the findings reveal vastly improved effects compared to K1.

The MK-4 form of vitamin K2 is the most rapidly absorbed and is now routinely used in Japan to maintain healthy bone density. MK-4, however, only remains active in the blood for a few hours.

The MK-7 form of K2, on the other hand, remains bioavailable to the human body over a sustained 24-hour period24 and to higher levels (seven- to eightfold) during prolonged intake.10 Both MK-4 and MK-7 have demonstrated remarkable health benefits when studied in human populations.

The Most Complete Vitamin K Formula – Super K

Vitamin K1 is the form found in plants and vegetables and should be part of most people’s daily supplement regimen. Even more important is inclusion of the MK-4 and MK-7 forms of vitamin K2.

Based on data substantiating the long-acting effects of MK-7, it is now possible to ingest fewer total micrograms of vitamin K but achieve far higher sustained blood levels of this critical nutrient.

The latest Super K with Advanced K2 Complex formula provides vitamin K1 and the MK-4 and MK-7 forms of vitamin K2 in just one daily softgel.

The virtue of this formula is that it provides the precise amount of the long-acting MK-7 form of vitamin K2 that recent human studies have shown provides optimal K2 levels over a 24-hour period. The MK-4 is included to provide the rapid increase in vitamin K blood levels that may account for its beneficial effects in certain studies.

Super K Supplement Facts

90 softgels

Item Catalog Number: 1834

Serving Size 1 softgel

Servings Per Container 90

Amount Per Serving
Vitamin C (as Ascorbyl palmitate)

10 mg

Vitamin K activity 2200 mcg

From:

Vitamin K1 (as phytonadione)

1500 mcg

Vitamin K2 (as menaquinone-4)

1000 mcg

Vitamin K2 (as menaquinone-7)

200 mcg

Other ingredients: extra virgin olive oil, gelatin, glycerin, beeswax, purified water, carob color.

Super K Dosage and Use

Take one softgel daily with a meal, or as recommended by a healthcare practitioner.

Super K Cautions

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult with your healthcare provider before taking Super K.

Super K Warnings

  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Super K is one of many products that is made by Life Extension. They are one of the number one nutritional companies and they make a very high quality product. We have decided to carry their products for this reason. If you find a product on their site at lef.org and you would like to purchase it, we can get it for you at their member pricing without you having to pay to become a member (This is a $75 savings). If this is of interest to you, please just call us at 813-655-4422 with the name of the item and we can get it for you.

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References

  • Vitamins

     

    1.  J Biol Chem. 2010 Jan 1;285(1):142-52. 
    2. Nature. 2003 Apr 24;422(6934):832.
    3. J Biosci. 2012 Jun;37(2):313-25.
    4. J Nutr Health Aging. 2001;5(2):70-4.
    5. JAMA. 2002 Jun 19;287(23):3116-26.
    6. J Bone Miner Metab. 2001;19(3):146-9.
    7. Osteoporos Int. 2007 Jul;18(7):963-72.
    8. J Bone Miner Res. 2007 Apr;22(4):509-19.
    9. Br J Nutr. 2009 Oct;102(8):1171-8.
    10. Blood. 2007 Apr 15;109(8):3279-83.
    11. Atherosclerosis. 2012 Dec;225(2):397-402.
    12. Adv Nutr. 2012 Mar 1;3(2):166-73.
    13. Thromb Haemost. 2008 Oct;100(4):593-603.
    14. Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10.
    15. Vitam Horm. 2008;78:393-416.
    16. Curr Drug Saf. 2006 Jan;1(1):87-97.
    17. J Nutr. 1999 Jun;129(6):1201-3.
    18. Br J Nutr. 2010 Sep;104(6):858-62.
    19. J Nutr. 2002 Sep;132(9):2609-12.
    20. Clin Calcium. 2007 Nov;17(11):1663-72.
    21. J Nutr. 2004 Nov;134(11):3100-5.
    22. Blood. 2007 Apr 1;109(7):2823-31.
    23. J Vasc Res. 2003 Nov-Dec;40(6):531-7.
    24. Nutr J. 2012 Nov 12;11:93. doi: 10.1186/1475-2891-11-93.
    25. Biochim Biophys Acta. 2012 Dec;1826(2):443-57.
    26. Redox Rep. 2010;15(1):11-9.
    27. Adv Nutr. 2011 Mar;2(2):78-88.
    28. Altern Med Rev. 2003 Nov;8(4):359-77.
    29. J Invest Dermatol. 2002 Apr;118(4):565-72.
    30. Radiat Environ Biophys. 2007 Mar;46(1):61-8.
    31. Free Radic Biol Med. 2007 Sep 1;43(5):853-9.
    32. PLoS Negl Trop Dis. 2012;6(7):e1729.
    33. Br J Nutr. 2003 Dec;90(6):1081-5.
    34. Am J Clin Nutr. 2006 Oct;84(4):830-4.
    35. In Vivo. 1994 Nov-Dec;8(6):1079-85.
    36. Ann Nutr Metab. 1990;34(2):85-92.
    37. Psychopharmacology (Berl). 2002 Jan;159(3):319-24.
    38. Am J Clin Nutr. 2007 Jul;86(1):145-9.
    39. Genet Test Mol Biomarkers. 2012 Sep;16(9):1001-6.
    40. Environ Toxicol Pharmacol. 2011 Jan;31(1):137-42.
    41. Acta Biochim Biophys Sin (Shanghai). 2012 Apr;44(4):330-8.
    42.Nig Q J Hosp Med. 2012 Apr-Jun;22(2):85-90.
    43. Toxicology. 2005 Jul 1;211(1-2):26-35. 
    44. Chem Biol Interact. 2001 Jul 31;137(1):75-88.
    45. Environ Health Perspect. 2000 Feb;108(2):105-8.
    46. Am J Ther. 2007 Mar-Apr;14(2):189-93.
    47. Am J Clin Nutr. 2000 Feb;71(2):530-6.
    48. Toxicology. 2002 Nov 15;180(2):121-37.
    49. J Am Coll Cardiol. 2003 Nov 5;42(9):1656-62.
    50. J Pediatr Gastroenterol Nutr. 2003 Jul;37(1):53-62.
    51. Cancer Sci. 2003 Apr;94(4):378-82.
    52. Adv Ther. 2002 May-Jun;19(3):151-9.
    53. Br J Dermatol. 1980 Jan;102(1):49-56.
    54. Respir Med. 2007 Aug;101(8):1770-8.
    55. Acta Obstet Gynecol Scand. 2007;86(7):783-7.
    56. J Int Med Res. 2012;40(1):28-42.
    57. Vopr Pitan. 1978 Jan-Feb;(1):44-8.
    58. J Am Coll Nutr. 1990 Apr;9(2):150-4.
    59. Jpn J Physiol. 1999 Apr;49(2):159-67.
    60. Indian J Med Res. 2002 Jul;116:29-34.
    61. Med Sci Monit. 2001 Jul-Aug;7(4):592-9.
    62. Int J Toxicol. 2005;24 Suppl 2:51-111.
    63. Int J Pharm. 2001 Jul 17;222(2):271-9.
    64. PLoS Med. 2005 Sep;2(9):e307.
    65. Ann N Y Acad Sci. 1992 Sep 30;669:7-20.
    66. Am J Clin Nutr. 1996 Jun;63(6):985S-90S.
    67. FASEB J. 1995 Apr;9(7):526-33.
    68. Altern Med Rev. 2003 Nov;8(4):359-77.
    69. J Nutr. 2007;137:2171-84.
    70. Am J Clin Nutr. 1999;69:1086-107.
    71. Curr Drug Targets. 2012 Dec 1;13(14):1757-71.
    72. Am J Clin Nutr. 2003 Jan;77(1):189-95.
    73. Lipids. 2012 Dec;47(12):1193-207.
    74. PLoS Med. 2005 Sep;2(9):e307.
    75. American College of Nutrition. Annual Meeting, October, 2009.
    76. FASEB J. April 2008;22 Meeting Abstract Supp:689.
    77. Available at: http://www.scientificfoodsolutions.com/ fastC_NBJ_Achievement_Award.html. Accessed January 31, 2013.
    78. Arch Biochem Biophys. 1993 Jul;304(1):176-80.
    79. J Cell Biochem. 1999 Jun 1;73(3):312-20.
    80. Free Radic Biol Med. 1999 Jan;26(1- 2):81-9.
    81. Lipids. 1992 Jul;27(7):543-50.
    82. Lipids. 1989 Dec;24(12):1043-7.
    83. Drug Nutr Interact. 1982;1(3):193-204.
    84. Nahrung. 2002 Dec;46(6):420-6.
    85. J Physiol Pharmacol. 2005 Sep;56 Suppl 4:197-201.
    86. J Biomed Sci. 2003 Mar-Apr;10(2):193-8.
    87. Photochem Photobiol. 2007 Mar-Apr;83(2):459-63.
    88. J Bone Miner Res. 2004 Aug;19(8):1221-30.
    89. J Bone Miner Res. 2006 Mar;21(3):397-405.
    90. Bone. 2008 May;42(5):996-1003.
    91. Steroids. 2001 Mar-May;66(3-5):375-80.
    92: Bone. 2006 Oct;39(4):946-53.
    93. Am J Clin Nutr. 2008 Aug;88(2):513S-519S.
    94. J Clin Endocrinol Metab. 2004 Jan;89(1):76-80.
    95. Am J Prev Med. 2011 Jul;41(1):68-74.
    96. Proc Nutr Soc. 2012 Feb;71(1):50-61.
    97. Med Hypotheses. 2011 Dec;77(6):1145-7.
    98. Dermatoendocrinol. 2011 Jan;3(1):11-7.
    99. Mol Cancer. 2011 May 18;10:58.
    100. J Invest Dermatol. 2012 Dec;132(12):2762-9.
    101. Anticancer Res. 2012 Jan;32(1):223-36.
    102. Proc Nutr Soc. 2003 Feb;62(1):117-22.
    103. J Chromatogr A. 2004 Oct 29;1054(1-2):227-33.
    104. Nahrung. 2004 Feb;48(1):34-7.
    105. J Am Diet Assoc. 1979 Dec;75(6):647-65.
    106. Am J Clin Nutr. 2001;74:714-22.
    107. Clinics (Sao Paulo). 2012;67(2):135-43.
    108.Oxid Med Cell Longev. 2012;2012:785743.
    109. J Vasc Surg. 2004 Jan;39(1):229-37.
    110. Diabetes Metab Res Rev. 2007 Oct;23(7):539-46
    111. Antioxid Redox Signal. 2002 Oct;4(5):791-8.
    112. Biol Chem. 2002 Mar-Apr;383(3-4):457-65.
    113. Genes Nutr. 2012 Jan;7(1):91-8.
    114. J Nutr. 2001 Feb;131(2):366S-368S.
    115. J Nutr. 2001 Feb;131(2):374S-377S.
    116. Circulation. 2007 Sep 25;116(13):1497-503.
    117. Asia Pac J Clin Nutr. 2007;16(3):422-8.
    118. Haematologica. 2002 Apr;87(4):420-6.
    119. J Am Coll Nutr. 2004 Jun;23(3):233-8.
    120. Fundam Clin Pharmacol. 2003 Dec;17(6):703-7.
    121. J Neurosci Res. 2004 Mar 15;75(6):845-53.
    122. Curr Eye Res. 2010 Sep;35(9):842-9.
    123. Neurobiol Aging. 2002 Sep-Oct;23(5):737-45.
    124.Alzheimers Dement. 2008 May;4(3):223-7.
    125. J Nutr Health Aging. 2002;6(6):392-404.
    126. Brain Res. 2001 Feb 16;892(1):211-7.
    127.Iran Biomed J. 2008 Oct;12(4):217-22.
    128. Toxicology. 2003 Jul 15;189(1-2):129-46.
    129. Br J Cancer. 2003 Jun 16;88(12):1948-55.
    130. Cancer Immunol Immunother. 2007 Jul;56(7):973-84. 
    131. Vitam Horm. 2007;76:393-418.
    132. Vitam Horm. 2011;86:179-215.
    133. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Mar;37(2):112-4.
    134. J Nutr. 1985 Jun;115(6):807-13.
    135. Eur J Nutr. 2008 Oct;47(7):387-92.
    136. Free Radic Biol Med. 2008 Mar 15;44(6):1203-8.
    137. Proc Natl Acad Sci USA. 1997 Apr 1; 94(7):3217-22.
    138. J Pharmacol Sci. 2011;115(3):408-16.
    139. Biofactors. 2000;11(1-2):11-3.
    140. Mol Cell Biochem. 2004 Jul;262(1-2):195-202.
    141. J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):383-92.
    142. Life Extension internal study.
    143. Atherosclerosis. 2005 May;180(1):19-25.
    144. Ann N Y Acad Sci. 2004 Dec;1031:401-4.
    145. Arch Pharm Res. 2008 Sep;31(9):1212-7.
    146. Clinics (Sao Paulo). 2009;64(3):235-44.
    147. J Atheroscler Thromb. 2010 Oct 27;17(10):1019-32.
    148. Free Radic Biol Med. 2011 Sep 15;51(6):1164-74.
    149. J Nutr. 2001 Nov;131(11):2892-7.
    150. Wei Sheng Yan Jiu. 2004 Mar;33(2):243-5.
    151. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728.
    152. Neuropharmacology. 2004 Nov;47(6):904-15.
    153. Indian J Exp Biol. 2011 Oct;49(10):732-8.
    154. Semin Urol Oncol 1999 May;17(2):85-90.
    155. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1771-5.
    156. FEBS Lett. 1998 Oct 16;437(1-2):145-8.
    157. Ann Nutr Metab. 2004;48(3):169-88.
    158. FASEB J. 2003 May;17(8):816-22.
    159. Free Radic Biol Med. 2004 Jan 1;36(1):1-15.
    160. N Engl J Med. 1996 May 2;334(18):1156-62.
    161. J Plant Physiol. 2005 Jul;162(7):790-6
    162. J Nutr Biochem. 2004 Jul;15(7):380-95.
    163. Nutrition. 2001 Oct;17(10):799-805.
    164. Mol Aspects Med. 2007 Oct-Dec;28(5-6):423-36.
    165. Annu Rev Nutr. 2007;27:347-62.
    166. Vitam Horm. 2007;76:1-21.
    167. Vitam Horm. 2007;76:45-65.
    168. J Biol Chem. 2008 Jun 27;283(26):17797-804.
    169. Am J Clin Nutr. 1997 Mar;65(3):785-9.
    170. Ann N Y Acad Sci. 1980;355:80-97.
    171. BMC Dev Biol. 2003 Jul 29;3(1):6.
    172. Prog Nucleic Acid Res Mol Biol. 2001;67:131-62.
    173. J Nutr Biochem. 2013 Jan 15. pii: S0955-2863(12)00281-1.
    174. Clin Nutr. 2012 Dec 28. pii: S0261-5614(12)00280-4.
    175. Curr Drug Metab. 2002 Apr;3(2):211-23.
    176. Am J Clin Nutr. 2003 May;77(5):1318-23.
    177. Curr Med Res Opin. 2007 Aug;23(8):1879-86.
    178. Nutrition. 2007 Mar;23(3):242-7.
    179. Int J Cardiol. 2007 Jun 12;118(3):345-9.
    180. Environ Health Perspect. 2009 Feb;117(2):254-60.
    181. J Photochem Photobiol B. 2010 Apr 2;99(1):49-61.
    182. Dig Dis Sci. 2010 Jun;55(6):1696-703.
    183. Br J Cancer. 2009 Jan 27;100(2):233-9.
    184. J Inherit Metab Dis. 2012 Jul;35(4):665-70.
    185. J Med Genet. 2011 Sep;48(9):590-2.
    186. Am J Cardiol. 2007 Feb 15;99(4):476-81.
    187. Lancet. 2007 Jan 20;369(9557):208-16.
    188. J Lab Clin Med. 1984 Jun;103(6):944-8.
    189. Am Fam Physician. 2010 Dec 15;82(12):1526-7.
    190. BMJ. 2004;328(7455):1535-6.
    191. Am J Clin Nutr. 2006 Jul;84(1):156-61.
    192. Br J Pharmacol. 2004 Mar;141(5):825-30.
    193. Circulation. 1998 Jan 27;97(3):237-41.
    194. N Engl J Med. 2002 Feb 14;346(7):476-83.
    195. Nephrol Dial Transplant. May 2002;17(5):916-22.
    196. Clin Chem. 2000 Aug;46(8 Pt 1):1065-71.
    197. Metabolism. 2011 May;60(5):673-80.
    198. Am J Clin Nutr. 1981 Mar;34(3):423-7.
    199. Am J Clin Nutr. 1980 Oct;33(10):2157-67.
    200. J Nutr. 1964 Mar;82:395-400.
    201. Mayo Clin Proc. 2008 Apr;83(4):470-8.
    202. Am J Cardiol. 2006 Feb 15;97(4):477-9.
    203. Arch Intern Med. 2002 Jul 22;162(14):1568-76.
    204. Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1783-9.
    205. JAMA. 2000 Sep 13;284(10):1263-70.
    206. Arch Intern Med. 2000 Apr 24;160(8):1177-84.
    207. Am J Cardiol. 2000 May 1;85(9):1100-5.
    208. Circulation. 1993 Jul;88(1):20-8.
    209. Am J Cardiol. 1998 Sep 15;82(6):737-43.
    210. JAMA. 1994 Mar 2;271(9):672-7.
    211. Neth J Med. 2004 Jul-Aug;62(7):229-34.
    212. J Clin Lipidol. 2012 Mar-Apr;6(2):121-31.
    213. Eur J Clin Pharmacol. 1991;40 Suppl 1:S49-S51.
    214. JAMA. 1990 Dec 19;264(23):3013-7.
    215. Am J Med. 2012 Oct;125(10):1026-35. 
    216. Farmakol Toksikol. 1988 Sep-Oct;51(5):82-6.
    217. Ideggyogy Sz. 2009 Jul 30;62(7-8):220-9.
    218. Am J Clin Dermatol. 2002;3(6):427-33.
    219. Vopr Pitan. 1987 Mar-Apr;(2):15-7.
    220. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112.
    221. Vitam Horm. 1991;46:165-228. Review.
    222. Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(10):34-9.
    223. Mol Genet Metab. 2012 Mar;105(3):463-71.
    224. Asian Pac J Cancer Prev. 2012;13(11):5333-8.
    225. Nutr Res Rev. 2001 Dec;14(2):257-66.
    226. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2195-201.
    227. Br J Nutr. 2007 Apr;97(4):764-9.
    228. Eur J Clin Nutr. 2003 Nov;57(11):1426-36.
    229. JAMA. 2002 Aug 28;288(8):973-9.
    230. Lancet. 2000 Feb 12;355(9203):517-22.
    231. Kardiol Pol. 2010 Mar;68(3):275-82.
    232. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.
    233. Am J Clin Nutr. 2009 Feb;89(2):693S-6S.
    234. Prev Med. 2004 Dec;39(6):1256-66.
    235. Am J Clin Nutr. 1999;70:904-910.
    236. Am J Clin Nutr. 2008 Aug;88(2):348-55.
    237. JAMA. 1997 Aug 27;278(8):659-62.
    238. J Am Geriatr Soc. 1986 Nov;34(11):800-6.
    239. Epidemiology. 2007 May;18(3):367-8.
    240. Lancet. 2002 Jan 19;359(9302):227-8.
    241. Asia Pac J Clin Nutr. 2007;16(1):103-9.
    242. Handb Exp Pharmacol. 2005;(170):325-38.
    243. Altern Med Rev. 2003 Feb;8(1):7-19.
    244. Cell Mol Life Sci. 2011 Dec;68(24):3963-9.
    245. Trends Mol Med. 2006 Jun;12(6):247-54.
    246. Med Secoli. 2007;19(1):9-18.
    247. Mol Genet Metab. 2007 Nov;92(3):222-8.
    248. Arch Med Res. 2002 Sep-Oct;33(5):439-47.
    249. Subcell Biochem. 2012;56:1-19.
    250. J Nutr. 2007 Jan;137(1):25-30.
    251. Diabetes. 2005 Nov;54(11):3073-81.
    252. IUBMB Life. 2002 Jan;53(1):25-36.
    253. Metab Brain Dis. 2004 Jun;19(1-2):125-34.
    254. Eur Neuropsychopharmacol. 1997 May;7(2):147-55.
    255. Bipolar Disord. 2000 Mar;2(1):47-55.
    256. Hum Psychopharmacol. 2011 Oct;26(7):526-30.
    257. Am J Psychiatry. 2006 Feb;163(2):210-6.
    258. Anxiety. 1996;2(1):51-2.
    259. Int Clin Psychopharmacol. 1999 Nov;14(6):353-6.
    260. J Clin Psychopharmacol. 2001 Jun;21(3):335-9.

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