Lower High Cholesterol
Improve Cardiovascular Disease
Reduce Risk Of Stroke
Support Healthy Insulin Sensitivity
Anti-inflammatory Agent For Rheumatoid and Osteo-arthritis

What Is It?

One of the newest and most effective cholesterol lowering alternatives to statin drugs is a recently patented proprietary formula comprising citrus and palm fruit extracts that contains polymethoxylated flavones and tocotrienols. It has been shown in human trials to significantly reduce total cholesterol, LDL cholesterol, and triglycerides. Additionally, the powerful antioxidant and anti-inflammatory properties of the extracts in this natural formulation (trademarked under the name Sytrinol™) are known to contribute to managing additional cardiovascular disease risk factors.

Nutrition Review

Polymethoxylated flavones (PMFs) are found in a variety of citrus fruits. The most common citrus PMFs, tangeretin and nobiletin, are found in the peels of tangerines and oranges. They are also found in smaller amounts in the juices of these fruits.

The researchers are currently exploring the compound's mechanism of action on cholesterol metabolism. They now suspect, based on early results in cell and animal studies, that it works by inhibiting the synthesis of cholesterol and triglycerides inside the liver.

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Health Benefits

Lower Total and LDL "bad cholesterol"

The cardio-protective and cholesterol-lowering claims for Sytrinol™ are supported by human trials. Two early trials, consisting of ten subjects each, measured the effects of Sytrinol in men and women diagnosed with hypercholesterolemia (elevated cholesterol) and screened to eliminate thyroid disorders, kidney disorders and diabetes. Subjects were instructed to maintain normal dietary habits and discontinue using vitamins, supplements and cholesterol-lowering medications for at least 6 weeks prior to, and during the study. Fasting blood samples were drawn at the onset and end of each 4-week trial, and plasma lipids profiles and other metabolic parameters were analyzed using standard methods.

The results from the first trial show that four weeks of treatment with Sytrinol (300 mg/day) caused significant reductions in: total cholesterol (-24%); LDL cholesterol (-19%); and triglycerides (-23%). There were no changes in HDL cholesterol levels, and body mass remained relatively stable.

In the second trial, subjects with elevated cholesterol again benefited from only four weeks of treatment with Sytrinol (300 mg/day). Treatment with Sytrinol caused significant reductions in: plasma total cholesterol (19.7%); LDL cholesterol (22.01%); apo B (20.9%); and triglycerides (28.4%). Additionally, subjects in the second trial benefited from a significant 5% increase in apo-A1, an important structural protein of HDL

Compared to placebo, total cholesterol was reduced 30%, LDL cholesterol was reduced 27% and total triglycerides dropped 33%. Additionally, HDL cholesterol levels increased by 4%, resulting in a significant reduction in the LDL/HDL ratio of 30%.

Nutrition Review

Special compounds in orange peel, called polymethoxylated flavones, have been shown in a series of studies to lower blood serum cholesterol and triglycerides. An experiment with hamsters showed that these compounds were effective in lowering the bad low-density lipoprotein (LDL)-cholesterol, and triglycerides. Other experiments showed that these actions were due to at least three mechanisms. These mechanisms involved the inhibition and transport of key parts of the LDL molecule. Another mechanism involved the activation of an important cell signaling molecule in liver cells which control lipid formation. Additional mechanisms by which the polymethoxylated flavones act to prevent cardiovascular disease are discussed.

United States Department of Agriculture (USDA)

Chemicals in citrus peel have strong cholesterol-lowering actions in animals. The biological mechanisms of these chemicals have been investigated, and have been shown to block the production of lipids (fats) and cholesterol by liver cells. An additional mechanism has been found to occur for one of these compounds, nobiletin. This study shows that nobiletin prevents atherosclerosis at the level of the vascular wall by inhibiting macrophage foam cell formation.

United States Department of Agriculture (USDA)

* A study published in the May 12, 2005 issue of the Journal of Agricultural and Food Chemistry showed that PMFs reduced cholesterol by 24.7 per cent.

* They can lower triglycerides by as much as 28 per cent by decreasing levels of diacylglycerol acetyl transferase, the liver enzyme needed to produce them. High triglycerides are directly linked to heart attacks and heart disease because they contribute to the formation of plaque in the arteries.

* Studies also show that PMFs can decrease apolipoprotein B, the specific protein your liver needs to create LDL cholesterol. This has resulted in a 23-per cent drop in LDL cholesterol.

* The anti-inflammatory action of PMFs has been documented for over 38 years – well before doctors even realized that inflammation is a key cause of heart disease. Recent research shows that they can lower an inflammatory marker known as C-reactive protein (CRP). High levels of CRP can put you in the danger zone, since this protein substance is tied more directly to heart-attack risk than any other factor.

As powerful as PMFs are on their own, they're even more effective at lowering bad cholesterol when they're used in combination with tocotrienols. Tocotrienols are a form of vitamin E found in palms, rice bran, and barley that have been shown to reduce LDL cholesterol by lowering the activity of HMGR.

So scientists combined these two powerful ingredients, PMFs and tocotrienols, into the patented formula called Sytrinol. The researchers who developed Sytrinol also tested it in vitro, in vivo, and most importantly on hundreds of human subjects, using the same scientific protocols used by drug companies.

The Healthier LIfe

Tocotrienols and cardiovascular disease

One of the most striking discoveries in tocotrienol research is their ability to clear atherosclerotic blockage (stenosis) in the carotid artery, giving them the potential to significantly reduce the risk of stroke. Stroke often occurs when atherosclerotic deposits travel upstream and cut off the blood supply to part of the brain.

Tocotrienols show promise as a natural and safe alternative to risky surgery for this condition because of their ability to reverse carotid stenosis, not merely stop its progression. This was demonstrated in a clinical trial testing the effect of tocotrienols on carotid atherosclerosis. The results of this 18-month trial were remarkable.

Fifty patients with carotid stenosis were randomly assigned to receive either 160 mg daily of palm tocotrienols (gamma and alpha forms) with 64 mg of alpha-tocopherol in palm oil, or palm oil only as a placebo. After 6 months the dosage in the treatment group was increased to 240 mg of tocotrienols with 96 mg of alpha-tocopherol.

At the end of the study, ultrasound scans of the carotid artery demonstrated that none of the patients in the control group had improved during the trial, while ten showed a worsening of their condition (increased stenosis). In the tocotrienol group, however, atherosclerosis was reduced and blood flow to the brain improved in 7 of 25 patients, while the condition had worsened in only two patients. No adverse side effects were reported in either group.

Tocotrienols and statin drugs such as lovastatin both lower cholesterol by suppressing the activity of the enzyme HMG-CoA reductase, although through different mechanisms. The statins are thought to affect the enzyme through competitive inhibition, while the tocotrienols accelerate enzyme degradation and decrease the efficiency of mRNA translation of the enzyme. This difference in mechanism is believed to be a reason for the absence of adverse side effects with tocotrienols, contrary to the common side effects of the statin drugs.

Some studies have demonstrated a significant reduction of both total and LDL cholesterol with tocotrienols administered to patients with high serum lipids. In a double blind, crossover study on 25 patients with high cholesterol levels, the patients in the treatment group were given 4 capsules daily of 50 mg tocotrienols mixed with palm oil, while the control group received only corn oil. At the end of the 8-week trial period, total cholesterol and LDL cholesterol had decreased significantly (15% and 8%) in the 15 subjects given the palm tocotrienols. There was no change in the control group.

Total cholesterol and LDL-cholesterol were reduced even more (17 % and 24 % respectively) when tocotrienols were added to a low fat, low cholesterol diet and alcohol-free regimen in another double-blind, longer-lasting trial (12 weeks).

Other important cardiovascular risk factors were reduced by tocotrienols. Apoli-poprotein B and lipoprotein(a), strong predictors of cardiovascular disease, as well as thromboxane B2 and platelet factor 4 were all significantly lowered in the tocotrienol-treated group (15%, 17%, 31% and 14% respectively).

Tocotrienols were studied in combination with the statin drug lovastatin in another study. The 28 patients with elevated cholesterol levels in this double blind, cross-over clinical trial were placed on the American Heart Association Step-1 diet before beginning the treatment. After 35 days on the diet, they were given low doses of lovastatin, tocotrienols and alpha-tocopherol (and combinations of these agents) in stages of 35 days each, while staying on the diet. The combination of lovastatin (10mg) and palm tocotrienols (50mg) had a lipid-lowering effect of 20-25%, while tocotrienols or lovastatin alone in the same dosages reduced LDL-cholesterol 18% and 15% respectively. No side effects were reported during the study. It is important to note that dosages of cholesterol-lowering drugs should not be reduced on the basis of this preliminary study.

Life Extension

Help support healthy insulin sensitivity

Citrus peel compounds that are known as polymethoxylated flavones may help support healthy insulin sensitivity, according to a recent study.

While citrus peel extract has been reported to improve cholesterol levels, this study was the first to examine its effects on insulin sensitivity. Scientists fed hamsters a sugar-rich diet for two weeks to induce insulin resistance and elevated triglycerides. The insulin-resistant animals then received either a low or high dose of the citrus flavones tangeretin and nobiletin. Supplementing with citrus flavones for four weeks helped reverse impaired insulin sensitivity.

Since insulin resistance, diabetes, and obesity are considered inflammatory disorders, the researchers also measured levels of two biomarkers of inflammation, tumor necrosis factor-alpha and interleukin-6. Levels of these biomarkers decreased in both groups receiving citrus flavones, as did serum levels of triglycerides and cholesterol .

These results indicate that citrus peel extracts may help fight insulin resistance and diabetes, as well as support healthy blood lipid levels.

Life Extension

Anti-inflammatory agent for rheumatoid and osteo arthritis

In particular, the flavonoid nobiletin has been identified as a novel anti-inflammatory agent that has the potential to inhibit the degradation of articular cartilage in osteoarthritis and rheumatoid arthritis. Nobiletin has also been found to interfere with numerous inflammatory cytokines, including interleukin-1 beta and interleukin-6. These anti-inflammatory effects are comparable to those seen with powerful anti-inflammatory steroids such as dexamethasone. Tangeretin , another citrus flavonoid, has been found to offer complementary effects against inflammation.

Life Extension

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Recommended Intake

Toxicity studies have shown that Sytrinol is well tolerated, with no toxic effects following consumption of polymethoxylated flavones in amounts of up to 1% of total dietary intake, or the equivalent of a 150-pound individual consuming almost 14 grams per day—that's nearly 50 times the recommended daily dosage of 300mg/day.

Natural Nutritional Foods Association 2004 abstract

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  • Check with your healthcare practitioner before taking Sytrinol.

  • If you are pregnant or lactating, consult your healthcare professional before using this product.

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    What Users Of These Ingredients Say...

    I have been taking these ingredients for over 1 year now.  It has been great!

    My blood pressure went from 160/101 to 115/75.  My total cholesterol went from over 300 to 201.  This all happened in less than 6 months after taking these ingredients.  

    Carter R.

    My husband and I wanted to let you know what our experience with these ingredients has been, even at this early stage. This Wednesday marks 4 weeks on the drink.

    Daniel is 42. His health is good except for the high blood pressure. He's been on Lisinopril and Indapam for about two years. He became a living zombie. It was a struggle for him some days to get the dishes washed and unload the dishwasher. He had almost every side effect listed for these drugs. In looking back, we realized that he is someone that is extremely sensitive to medicine and responds very quickly to them (either way).

    We received the shipment on Wednesday, March 16th, and he began taking it.
    His energy began coming back the following Monday, and has remained (and gotten better).

    On Friday, April 1 he had to
    stop taking the diuretic medicine because his blood pressure was dropping too low. Once this diuretic was stopped, everything leveled out within the target range.

    He began having another symptom of skin rash/eczema and I got on the Internet to find out more about ACE inhibitors. Once we found out it was based on the venom of a Brazilian pit viper snake, the symptoms he's been experiencing were completely understandable.

    He's now cut his ACE inhibitor in half, and is still in the target range on the blood pressure. We feel like that with a bit more time on the formula, he will be off of these medicines.

    These ingredients have given me my husband back.

    Thank you so much!

    Best regards,
    Ann and Dan R .

    I am 45 years old and have been diagnosed with having high blood pressure (150 over 93). Because of my medical plan changing I have seen several different doctors, over a 2 year period, all are family practitioners. Each doctor prescribed different blood pressure medicine which I took and followed there direction. I saw no difference in my blood pressure. My biggest problem was with the side effects of each drug.

    Then my life changed when I started taking these ingredients. I have seen my blood pressure drop to 125 over 79 in 2.5 months. I no longer take blood pressure prescription medication and my doctor considers my blood pressure to be normal, I agree. Thank you.

    Brent M.

    My mom died of a stroke at age fifty... My oldest brother died of a congenital heart problem at football practice at 16. My dad died at seventy of heart problems after suffering with bad circulation that limited, for many years, his ability to walk.

    At age sixty I am 5' 9" and 163 lbs. I had been working out at a gym for six months and had all but eliminated alcohol. At an annual physical in early March, I was disappointed to learn that my blood pressure, for which I had been taking metoprolol, was 168/98.My doctor, an internal medicine guy who was tired of seeing his patients going down with heart attacks and strokes, made it clear that he viewed me as a "walking time bomb." Given the family history that I have to work with, it was impossible to argue and I put up only modest resistance when he prescribed Lipitor. Soon after I began taking these ingredients my daily readings began to go steadily down and the most recent lab results show:

    LDL at 72 or one half of what it was a month ago

    HDL 49, up 6 from a month ago

    Triglycerides 82, down from 102

    Blood pressure at 123/68.

    My doctor was delighted. Me too. If the trend continues, he has promised to review the need for Lipitor and maybe even metoprolol. I will be one happy man to see those things go.


    Two months ago, despite swimming and jogging for an hour each day, my blood pressure was 187 over 98. I freaked. After using these ingredients for just
    9 weeks now I am already down to 144/84. I know that it takes most people 3 months to get it down but I am very pleased so far.

    Jack O

    I have been using these ingredients for 2 1/2 months and my blood pressure has dropped from about 180/100 to an
    average of 125/80. This decrease occurred without other medication. My doctor wanted to put me on an ace-inhibitor medication but I decided to take these ingredients instead. I'm glad I did.

    J Patterson

    In December 2005, during a physical my blood pressure was 149/95. My cholesterol was 267. I was headed for a stroke. My wife's physician had suggested liquid arginine for high blood pressure and she found these ingredients on the internet.

    My blood pressure is now a perfect 120/80 and my cholesterol is down to 222 so far. My doctor is so pleased that he decided to keep me OFF the medications.


    Hi. This is Heidi. My husband has been taking these ingredients. His blood pressure was 144/83. Not real high, but high enough to become a problem.
    His blood pressure now is averaging from 125 to 118. Well within normal range. He seems much more relaxed. I am convinced that this is helping him. It is just by a stroke of luck that I found your website. I am going to tell other people with similar conditions.

    We are still working on losing the weight, but that takes a little time.

    Thank you, and take care,

    Heidi D.

    These ingredients are something that I have found great success with... the formula works, just as the advertisements say.

    I have had several strokes, fortunately having survived with no noticible problems. I previously have had 'spikes' of high BP readings, meaning in the 170's to 190's but, after 3 months of taking these ingredients, I am happy to say the I am settled into the 117 to 128 BP readings. only 1 time, have I had a reading above, and that was 144/73. I can live with that.

    Joyce C.

    The information herein is not intended to replace the medical advice of your physician. You are advised to consult with your physician with regards to matters relating to your health, and in particular regarding matters that may require diagnosis or medical attention. DO NOT stop taking medications without first consulting with your physician. These statements have not been evaluated by the Food and Drug Administration.

    Every effort has been made to ensure that the information provided herein is accurate, up-to-date, and complete, but no guarantee is made to that effect. This information has been compiled for use by healthcare practitioners and consumers in the United States. does not endorse drugs, diagnose patients or recommend therapy. This informational resource is designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. does not assume any responsibility for any aspect of healthcare administered with the aid of information compiles. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions, check with your doctor, nurse or pharmacist.