Arginine (L- Arginine) – Learn How It Can Help You

Arginine – What Is It?

L-arginine is one of many ingredients in the Tikva product. It is a semi-essential amino acid that has numerous functions in the body. It helps dispose of ammonia, is used to make compounds in the body such as nitric oxide, creatine, L-glutamate, L-proline, and can be converted to glucose and glycogen if needed.

 Nobel Prize Discover

Nobel PrizeNitric oxide (NO) is a gas that transmits signals in the organism. The discoverers of NO as a signal molecule was awarded the Nobel Prize in Physiology in 1998 for the discovery that “nitric oxide is a signalling molecule in the cardiovascular system”.

Research confirmed that NO is a signal molecule of key importance for the cardiovascular system and also serves many other functions.

We now know that nitric oxide (NO) acts as a signal molecule in the nervous system, as a weapon against infections, as a regulator of blood pressure and as a gatekeeper of blood flow to different organs.

  • When NO is produced by the innermost cell layer of the arteries, the endothelium, it rapidly spreads through the cell membranes to the underlying muscle cells. Their contraction is turned off by NO, resulting in a dilatation of the arteries. In this way, NO controls the blood pressure and its distribution. It also prevents the formation of thrombi.
  • When NO is formed in nerve cells, it spreads rapidly in all directions, activating all cells in the vicinity. This can modulate many functions, from behaviour to gastrointestinal motility.
  • When NO is produced in white blood cells (such as macrophages), huge quantities are achieved and become toxic to invading bacteria and parasites.

In atherosclerosis, the endothelium has a reduced capacity to produce NO.

However, there are now several natural ways to get nitric oxide (NO) into the arteries. These include Arginine, Citrulline, and Pomegranate.

Arginine Health Benefits

Reducing high blood pressure

Arginine-derived nitric oxide created by the endothelial cells lining your arteries is now known to be the principal blood pressure regulator of the body.

argininebloodvesselOnce produced and released by the endothelium, nitric oxide causes the arterial smooth muscles making up the vessel walls to relax, enlarging the interior diameter of the artery, and ultimately letting more blood flow through.

A study which was first presented in November 1997 at the American Heart Association’s 70th Scientific session and later published in Circulation, looked at patients ranging in age between thirty and seventy and suffering mild to moderate hypertension (ie., blood pressure greater than 160/90 mm Hg). The researchers found that an supplementation of 6,000 milligrams (6 grams) per day worked to lower their blood pressure significantly.

One study that appeared in the Journal of the American College of Cardiology in 1998 looked at fourteen patients in Italy newly diagnosed with borderline high blood pressure. The researchers found that it took only two grams a day of L-arginine administered orally for a week to trigger nearly twenty point drops in systolic blood pressure – a fact they credited to l-arginine’s ability to improve endothelial function.

-Robert Fried, Ph.D., and Woodson C. Merrell, M.D., The Arginine Solution (Warner Books, 1999)

Lowering cholesterol

It also appears to benefit individuals with high cholesterol. In 1997, Stanford researchers showed that in people with elevated cholesterol, arginine reduced the tendency of blood platelets to clump, potentially lessening the risk of heart attacks and strokes. An earlier study at Sinai Hospital in Baltimore found that two weeks of arginine therapy reduced total and LDL (“bad”) cholesterol but had no effect on HDL (“good”) cholesterol in healthy elderly volunteers.

Relieving angina

A 1998 Mayo Clinic study found that patients with early heart disease who took arginine supplements for six months had better blood flow to the heart and less angina compared with a placebo group. And Polish scientists showed that arginine increased the exercise capacity of patients with angina who had had a heart attack.”

-Robert Fried, Ph.D., and Woodson C. Merrell, M.D., The Arginine Solution (Warner Books, 1999)

Boost Immunity

“Preliminary evidence suggests that this supplement may also boost immunity, reverse impotence, and forestall many of the complications of diabetes. For example, it is known that the immune system can kill infectious microbes, from Salmonella to Chlamydia, by emitting a puff of nitric oxide.

Several studies have now shown that supplementation can activate the immune system and spur wound healing after surgery or trauma.

Aid in Erectile Dysfunction

It promotes natural nitric oxide production in the body. By enhancing nitric oxide and subsequent cyclic GMP synthesis, arginine enlarges blood vessels in the corpus cavernosum that can lead to enhanced sensation and penile erection. It is given to prize race horses at stud to improve the frequency of their sexual encounters, and to improve the quality of their sperm.

Arginine Dialates blood vessels like viagraLike the new prescription potency drug Viagra, arginine works to boost cyclic GMP levels. Arginine causes the production of nitric oxide that leads to increased levels of cyclic GMP. The longer that cyclic GMP levels are maintained, the better the chance of achieving and maintaining an erection. (One benefit of arginine supplementation is that it is much less costly than Viagra.)

The dose of arginine needed to enhance sexual function has been estimated to be between 6 and 12 grams a day.

-Life Extension Foundation


Finally, arginine blood levels are often reduced in diabetes, and some evidence suggests that arginine can slow the progression of atherosclerosis in those with the disease. It should not, however, be taken by people with diabetic retinopathy.”


“In the field of medicine and health it is one of the revolutions of our time: the discovery that the amino acid L-arginine may be a ‘magic bullet’ for the cardiovascular system. A virtual arterial cleanser, ARGININE helps eliminate blockage and maintains blood flow.

”“Oral ARGININE taken regularly has time and time again proven its ability to lower cholesterol, prevent LDL oxidation by free radicals, restore endothelial function, normalize blood-vessel dilation, reduce platelet stickiness, and generally tune up your cardiovascular system.”

-Woodson Merrell, M.D., Columbia University Medical School

Dr. Robert Fried, PhD., Senior Professor of Biopsychology at Hunter College, Columbia Univ. NY

L-ARGININE is a safe, effective, and inexpensive means of self-care that
boosts immunity, sexual potency, and general well-being.”

-Harold Bloomfield, M.D.

7 grams of L-arginine per day
improved blood flow in men, aged 55 to 77, with elevated serum cholesterol and early coronary artery disease.


L-arginine supplementation
reduced pathological increases in the thickness of plaque lined vessel walls in people with elevated cholesterol and artherosclerosis.


Arginine lowered plasma cholesterol levels in patients with advanced

-New England Journal of Medicine

Arginine infusion has the same effect in cardiovascular patients as cholesterol-lowering drugs.

-The Lancet


7 grams of L-arginine improved blood-vessel relaxation in young men with elevated serum cholesterol and coronary artery disease (in as few as 3 days).


Cardiovascular CureIn the best selling book “The Cardiovascular Cure,” the author John Cooke, Ph.D. states that arginine derived nitric oxide (ADNO):

Keeps blood vessels pliable and elastic

• Keeps blood flowing smoothly

• Keeps platelets calm and prevents them from sticking to the vessel wall

• Keeps white blood cells calm and prevents them from sticking to the vessel wall

• Reduces growth and multiplication of muscle cells that thicken the vessel wall

• Slows plaque growth and suppresses atherosclerosis

• May melt away plaque that already exists

To date arginine has been shown in animal as well as human trials that it may be effective in the following:

Decreasing and reversing atherosclerosis by decreasing intimal thickening and monocyte accumulation 9,10,11,12,13,14

• Restore normal endothelial function in hypercholesterolemia 14,15,16,17,18,19,20,21

Reversing consequences of coronary artery disease 22,23,24,25,26,27,28,29,30

Decreasing cholesterol and triglycerides 32

Improves walking distance in peripheral vascular disease 31,33,34,35,36

• Improves pain in interstitial cystitis 37,38

• Prolonged administration of arginine reverses adverse effects of high blood pressure 39,40,41,42

Decreases high blood pressure 43

• Decreases post operative infection and length of stay 44

Increases human growth hormone 45,46,47,48,49,50,116

• Improves outcome after bypass surgery 51

Improves sexual function 52

Improves exercise tolerance 53,54

• Improves renal function 55,56,57,58,59,60

• Improves glucose uptake in muscle cells 61

Improves asthma 61,62,63,64,65,66

• Improves cell mediated immunity 67,68,69,70,71

• Improves pituitary responsiveness and modulates hormonal control 72,73,74

• Improves muscle performance 75

Improves diabetes and reverses damage 76,77,78,79

May prevent diabetes 78

Reduces blood clots and strokes 80,81,82

• Helps prevent restenosis after angioplasty and bypass 83,84,85

• Helps prevent post surgical damage after intestinal manipulation 86

May improve irritable bowel syndrome 87

Improves osteoporosis 88

• May improve prostate function 89

• May give protection against size of heart attack 90

• Helps protect in cardiac transplants 91,92

• Improve scleroderma 93

Improve sickle cell disease 94

• Prevent pre-eclampsia 95

• Improves exercise capacity in pulmonary hypertension 96,117,118

• Improves wound healing 97,98,99

Reduces ulcers 101,102

Improves peripheral vascular disease 103,104

• Improves outcome in sepsis 105

Improves conditions of heart failure 106

• Improves outcome of cancer treatment 107,108

Improve alzheimer’s 109,110,111,112

Improves memory and cognitive functions 113,114,115

• L-arginine has been shown to safe in the above studies as well as others 100,116

-The Cardiovascular Cure

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